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Creatine and Memantine: User Report- Three weeks. Surprising results and Sources

As a long-time sufferer of intrusive cyclical-ruminating thoughts, along with poor auditory and working memory, which has resulted in a history of poor academics and work station; no matter how hard"I try".Academic history: Low GPA, bilingual with a tendency towards novelty-seeking, though I tried in earnest to be a good student and spent many hours studying with tutors and trying to master the material asked of me. Successful work environments: Worked as an Assistant Manager in an Industrial Engineering capacity for a large logistics company... even though I really had no idea what I was doing. I learned the value of understanding systems and databases, which I applied in my research...( In my sources below). Diagnosed with BiP Type II, inattentive ADHD, allergies and Asthma...I think I've stumbled upon a combo that provides a number of noticeable improvements in my quality of thinking/life... They are as follows:
  • Not quick to fluster or get frustrated as before(significant)
  • Auditory and visual working memory has improved to the point where I can recall phone numbers more easily than before and remember spoken instructions for longer periods of time. I can also have conversations without losing my train of thought.
  • Social interactions are not nearly as taxing or exhausting as they were before.
  • Much less "tip of the tongue" moments, or forgetting things when in a stressed state.
  • Significant decrease in allergy symptoms and asthma symptoms(huge)
  • Increased muscle tone and desire to drink water without urinating as much(Not my goal, but I'll take it).
  • Do not feel the need to drink nearly as much coffee as I use to and consume sugary/starchy things.
  • Improved social interactions with much less anxiety than before(significant).
  • My sense of smell has returned. Something I have not had in several years.
  • Not always craving sugary things (Mentioned twice because this is a biggie for me; though I am underweight)
  • Significantly improved quality of sleep.
  • Significantly improved social interactions and much less distractibility in noisy environments.
  • Desire to exercise and not tire as quickly as before.
  • Huperzine-A appears to last longer than before I started taking Memantine and Creatine...Hup-A lost it's noticeable effects after less than an hour and now seems to last around 3 hours...Yes, I understand it has a 14 half life and must be used cautiously.
  • Much less distracted by my environment (huge).
Amounts: 20MG Memantine before bed and 5G of Creatine in the morning.Time Taken for both: Three weeks.
Question: Any idea what other substances I can take to enhance the positive effects I am experiencing?
I hope the aforementioned observations are useful for someone who might have similar ailments as myself. Of course, check with your doctor first. Below, you'll find my sources and summaries on the subject.
**Sources and theory(s) for why I picked Creatine and memantine( Below):**Note: Memantine: I became interested in substances working off of the NMDA pathway after I noticed I felt a reduction in ADHD symptoms when taking COQ10, L-Carnitine and Vitamin C; which work off of the NMDA pathway...At least that's my understanding. Creatine Monohydratee: I became interested in this substance after learning of its importance in cell regeneration of the Mitochondria, specifically in a process related to ATP...Both implicated in certain instances of ADHD, Asthma and Allergies.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028535/"Title: Mitochondrial dysfunction increases allergic airway inflammation"" In conclusion, we have provided evidence that preexisting oxidative damage to mitochondria, prior the recruitment of inflammatory cells to the airways, intensified airway eosinophilia, increased mucin production, as well as enhanced bronchial hyperresponsiveness. Our findings further emphasize the role of mitochondria in the pathogenesis of allergic airway inflammation and asthma. Furthermore, they also imply that prevention or reduction of oxidative mitochondrial damage in the airways may have a beneficial role in therapy of these diseases"
http://vivo.med.cornell.edu/display/pubid65249129156Title: Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases
"This review discusses the contribution of mitochondria and bioenergetics to the progression of these neurodegenerative diseases and investigates the potential neuroprotective value of creatine supplementation in each of these neurological diseases. In summary, current literature suggests that exogenous creatine supplementation is most efficacious as a treatment paradigm in Huntington's and Parkinson's disease but appears to be less effective for ALS and Alzheimer's disease."
https://lpi.oregonstate.edu/mic/dietary-factors/coenzyme-Q10Title: Linus Pauling Institute: COQ10
  • "Oral high-dose coenzyme Q10 is usually effective to treat mitochondrial disorders that are caused by mutations in coenzyme Q10 biosynthetic genes. (More information) "
  • The conversion of energy from carbohydrates and fats to ATP, the form of energy used by cells, requires the presence of coenzyme Q10 in the inner mitochondrial membrane. As part of the mitochondrial electron transport chain, coenzyme Q10 accepts electrons from reducing equivalents generated during fatty acid and glucose metabolism and then transfers them to electron acceptors. At the same time, coenzyme Q10 contributes to transfer protons (H+) from the mitochondrial matrix to the intermembrane space, creating a proton gradient across the inner mitochondrial membrane. The energy released when the protons flow back into the mitochondrial interior is used to form ATP (Figure 2) (1). In addition to its role in ATP synthesis, mitochondrial coenzyme Q10 mediates the oxidation of dihydroorotate to orotate in the de novo pyrimidine synthesis.
https://onlinelibrary.wiley.com/doi/abs/10.1002/hup.2687Title: "The effect of memantine in adult patients with attention deficit hyperactivity disorder" The results of this study indicated that memantine was effective in reducing symptoms of Inattention/Memory Problems, Hyperactivity/Restlessness, Impulsivity/Emotional Lability"
https://www.webmd.com/alzheimers/guide/nmda-receptor-antagonists#1
Title: NMDA Receptor Antagonists and Alzheimer's(memantine)
https://patents.google.com/patent/EP0911026A1/enTitle: Creatine derivatives for asthma" Therapeutic agents for asthma in the present invention means a drug used for so-called treatment performed in the hope of remitting the symptoms of asthma, and preventive treatment. It is known that creatine, a typical compound used in the present invention, is deeply involved with ATP (adenosine triphosphate) which is a kinetic energy. (See, e.g., Roger Hariss, Eric Hultman, Clinical Science (1993): 84, 565 - 5711.) However, no effect of such compounds as creatine for asthma has been known yet. The chemical formula of creatine is as shown in the chemical formula 2 below"" Seven asthmatics (average age; 40, 4 males and 3 females) took 4 g/day creatine orally, and all of showed improvement of pulmonary function and decreased in frequency of on-demand uses of β2-stimulant-inhalants"*"*Thus, the drug of the present invention has an excellent inhibitory effect against the delayed-type asthmatic reaction in bronchial asthma. Also the drug of the present invention has no side effect and is safe for the human body"
https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-015-0390-6Title: ATP regulation in bioproduction" The strategies used to enhance ATP supply are categorized as follows: addition of energy substrates, controlling pH, metabolic engineering of ATP-generating or ATP-consuming pathways, and controlling reactions of the respiratory chain."

The addition of citric acid effectively increases the ATP supply. The elevated ATP supply improves the tolerance of Candida glabrata to extracellular pH values of 4.5–5.0 and enhances the yield of pyruvic acid [19]. Addition of citric acid as an auxiliary energy substrate for dehydrogenase reactions by malic enzyme that generate NADH enhances the contribution of electrons from NADH, which pass through the electron transfer chain to generate a proton-motive force that enhances respiratory ATP synthesis via membrane-localized FoF1-ATP synthase [19]. Citric acid addition increases the cytosolic pH and decreases the vacuolar pH. This result led to the proposal that the elevated ATP supply induced by citric acid addition enhances V-ATPase to transport H+ from the cytosol to the vacuole, which improves tolerance to acidic pH that is accompanied by an increase in cell growth that, in turn, increases the yield of pyruvic acid [19].
Moreover, enhancing the ATP supply by up-regulating the expression of genes encoding citrate lyase, malate dehydrogenase, and malic enzyme, which are components of the citric acid pathway (Fig. 3), by 10- to 120-fold caused by addition of citric acid is effective for producing pyruvic acid biosynthesis in Lactobacillus panis [20]. During the stationary phase of growth, enhanced pyruvic acid production increases the amount of acetic acid available to generate ATP through acetate kinase. Further, enhanced pyruvic acid production increases lactic acid biosynthesis through lactate dehydrogenase (Fig. 3) and lactic acid export through a citric acid-lactic acid exchanger [20] that reduces ATP consumption required to maintain the pH in L. panis [20]. Overall, the increase in the ATP supply due to enhanced ATP generation and reduced ATP consumption induced by the addition of citric acid increases cell growth and lactic acid production.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893446/Title: The Potential Influence of the Bacterial Microbiome on the Development and Progression of ADHD" The seminal study by Pärtty et al. researched the effects of probiotic use on the development of ADHD in children by randomly administering strains of Lactobacillus rhamnosus into 75 infants. The infants were monitored at three weeks, 3, 6, 12, 18 and 24 months, and finally, at 13 years of age. The authors concluded that at the age of 13 years, ADHD was diagnosed in 6/35 (17.1%) children using the placebo, whereas no children had this disorder in the probiotic group. These results, even if encouraging, do not identify any specific composition of the microbiota to the neurodevelopmental disease, and thus, might mean that probiotics decrease ADHD in a different way rather than influencing the composition of the microbiome [142]. However, it is important to conclude that these findings potentially represent a method to reduce the risk of developing ADHD "
" The various steps of the kynurenine pathway are dependent on coenzymes, such as the activated form of vitamin B6, pyridoxal 5′-phosphate (PLP). One study found an inverse correlation between serum levels of vitamin B6 and ADHD including its symptom severity [94]. Similarly, Aarsland et al. also observed a decrease in vitamin B6 in their patient group. Other data suggested that vitamin B6 metabolism plays a key part in the pathophysiology of ADHD, as vitamin B6 dependent enzymes show severe abnormalities in the ADHD test group [95]. Thus, lower levels of intermediate metabolites could be related to a deficiency of enzyme substrate. This data supports the importance of optimal coverage of ADHD patients with vitamin B6. The microbiome could play a potentially important role, as bacteria in the large intestine produce this vitamin [96]. As the correlation between levels of vitamin B6 and ADHD are relatively new, future studies are warranted to asses to what extent the microbiome can influence vitamin B6 levels on a therapeutic level. "
" lterations in the GABAergic system have been associated with neurodevelopmental diseases, such as autism spectrum disorder and ADHD. This system is especially susceptible to alterations during development as GABAergic neurons originate from a different part of the neural tube than GABA′s most important counterpart, the glutamatergic system. ADHD symptoms may be explained by the hypothesis that inhibitory functions of the cerebral cortex are reduced, leading to a reduction of filtering sensory influences, and finally having difficulties choosing the right behavioral reaction [138].
As described above, several studies have associated low levels of cerebral GABA concentrations with symptoms of ADHD [139,140,141]. Furthermore, a randomized controlled study showed that Lactobacillus rhamnosus also has a preventive effect as the administration of this bacterium in the first six months of life reduced the risk of ADHD and Asperger Syndrome (AS) [142]. The positive effects of this species may be due to the fact that Lactobacillus rhamnosus is, on the one hand, implicated in the development of tight junctions responsible for a strong gut barrier, and on the other hand, important for the immunoglobulin A and mucin production [143].
Various factors influence the development of ADHD, among which the neuroinhibitory neurotransmitter GABA seems to play a crucial role. However, to what extent low levels of Lactobacillus spp. and decreased concentrations of GABA are associated and how they precisely affect the development of ADHD remains unclear and has to be thoroughly investigated."
" Another study, however, using 871 European newborns examined the effects of early antibiotic treatment on cognitive functions with the help of IQ and reading tests, and on symptoms of ADHD using the mentioned Conners Rating Scale-Revised (CRS-R). Thereby they discovered that children who consumed antibiotics in the first year of life showed a reduced reading ability score, higher scores on the CRS-R, rated by parents, and increased symptoms of ADHD at the ages of 7–11 years. Nonetheless, this association was not made for babies and children that used antibiotics between the ages of 12 months and 3.5 years. This indicates that one of the vital factors for developing ADHD is the age in which the newborn consumes the antibiotics. It seems that during the first 12 months of life, important developments of the gut-brain axis take place, which when disrupted influence the neurodevelopment, and thus, the CNS in the long run [12]. These data, however, must be interpreted with caution, as this was not an RCT. Accordingly, direct causation between the antibiotic use and later seen ADHD cannot be correctly made [199]"
Tags:ADHD; Working Memory; Allergies; Cyclical Thoughts; Creatine; Memantine; NMDA; Memory; ATP; Probiotic
Special note and gratitude: I had several years of early adversity and less than ideal teachers during a time when ADD was just being clinically treated. These cycles of less than ideal teachers led to a sort of self-reinforcing dynamic where my frustration of fear to not understand the material asked of me, led and or contributed to all kinds of behavioral problems. Thank's in large part to a wonderful Tutor I've had the pleasure of working with, I've been able to really trust my instruction for the first time. I am super grateful for this. Another kind of odd anomaly is my Mom and Dad are high functioning and I was treated by the teaching apparatus as lazy...When I was sincerely trying in earnest.
submitted by Citynaut to Nootropics

[H] SWSH Pokémon, Seed Checking services, RNG Services from Gen (1-7), Ranger Manaphy RNG, Breeding Dittos, Shiny VC Breedjects, Objects, RNG Colo/Channel Jirachi/Celebi Services, SR/RNG XD/Colosseum Services, Cap Pikachus and Meltan/Melmetal. More inside [W] PayPal

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· 1 Pikachu and Eevee Tracksuit Codes. 8USD+Fees
· Breeding Services on SWSH for any Ball, IVs, Nature and HAs. I completed Pokédex so I can do any.
· All Sword and Shield Objects less Key ones.
· Zacian/Zamazenta customized (Ball, Nature(Mint), IVs(Bottle Cap), TAG and OT)
· Kubfu/Urshifu customized (Nature (Mint), IVs (Bottle Cap), TAG and OT)
· Crown Tundra Legends (Calyrex, Galar Birds, Spectrier, Glastrier, 6 Regis, Virizion, Cobalion, Terrakion, Keldeo, Cosmog, Dynamax Adventure ones) customized (Ball, Nature(Mint), IVs(Bottle Cap), TAG and OT)
· Raid Seed Check Services 0,20€ each try
· Meltan & Melmetal: Once the deal is done the usser will have to wait between 1-2Weeks until I get 400 Candies (More or less). Usser will be able to choose the Nature, Nickname and Ball of the Melmetal and will have SPA Tag. Prices are 0.50€ Meltan and 7€ Melmetal or 6€ if you buy both. 1 Melmetal Ready available
· All 5 Event USUM Cap Pikachus Set RNG Services. 5USD each and 20USD for all
· Colosseum/Channel Jirachi, Ageto Celebi and Colosseum Pikachu (See Spreasheet): Dolphin Emulator + RNG Reporter + VBA-M + Ruby/Sapphire Save Files. I can RNG Nature for Celebi and Pikachu (I can see what nature and IVs I’ll get before transfer). Channel/Colosseum Jirachi are available to RNG Nature and Shiny (For Channel Shiny ones right now I have Jolly/Careful Seed found but you can ask for any nature and I’ll try to get it).
-WISMKR Jirachi 5USD Normal/10USD Shiny
-CHANNEL Jirachi 10USD Normal/12USD Shiny
-Ageto Celebi 7USD Random/13USD with Nature
· Pokémon Box Mons. Dolphin Emulator + RNG Reporter + VBA-M + Ruby/Sapphire Save Files. I can SR Nature and RNG Shiny(Star or Square) but no IVs. More info in the SpreadSheet.
· RNG/SR XD/Colosseum Mons Services (See Spreasheet). Square Shiny and TID/SID RNG is Available for both games (To get good Spreads). (Dolphin Emulator + RNG Reporter + PokeFinder + XD/Colosseum Saves)
Colosseum: RNG is Available for ALL Noiseless Zones Pokémon for Pokémon Colosseum (Such as Entei and Suicune) and some few Noise Zones ones (Check Spreasheet). Completed a Self RNGed Collection less 13 Noisy Zone Shadows and JP e-reader ones aren’t available due to I don’t have Card files to get them legit.
XD: ALL Available (Completed a Self RNGed Collection) such a Shiny Johto Starters/Eevee/HORDEL Elekid, Shadow Mons (Shiny Locked) and Shiny PokeSPot Pokémon.
· Manaphy Egg RNG Service: OT, Nature, IVs and Shiny. Pokémon Ranger 1 Cartridge + TWLSaveTool + Gen4 Games + Desmume Emulator + Lua Scripts + RNG Reporter.
5€ Normal+IVs, 10€ Shiny and 12€ Shiny+IVs
· RNG Service from Gen1-7. Mons will be proofed and you can choose the OT of mons (Gen1-7), also you can ask for different types of RNG that aren’t listed.
- Gen3 (RSE/FRLG): Visual Boy Advance Emulator + Lua Scripts + RNG Reporter. Available RNG: Legends (Event not allowed)/Gifts/Safari/Wild/GameCorneStarters/Eggs and Square Shiny service available
- Gen4 (HGSS/Platinum): Desmume Emulator + Lua Scripts + RNG Reporter. Available RNG: Legends (Event not allowed)/Events(Regis/Sinjoh Ruins)/Gifts/Starters/Wild/Game CorneEggs/ID-SID RNG and Square Shiny.
- Gen5 (BW/BW2): Desmume Emulator + Lua Scripts + RNG Reporter. Available RNG: Dream Radar Legends(Less Palkia)/Wild/Gifts/Starters/Legends. *Entree Forest for DW Mons is available but you have to provide the save with Legit Mons
- Gen6 (XY/ORAS): NTR + PCalc + 3DS RNG Tool. Available RNG: Starters/Unowns/Event (Latios or Latias)/Eggs(TSV too)/Legends (Less Groudon and Kyogre for now) and Square Shiny service available
- Gen7 (USUM): NTR + PCalc + 3DS RNG Tool. Available RNG: Starters (USUM), Wormhole Legends/UBs (Wild Included), Stacionary Legends, Gift Pokémon and Eggs (TSV too)/TSV RNG. Ash Greninja and Square Shiny service available
I can breed all Vivillon Patterns less 3 due to I created a new save file with the Region of my PAL DS changed. The only ones I can’t breed are Elegant because is only for Japanese DS Regions and Modern/Savanna because are for American DS Regions.
- Gen1/2 (Y/S/C). Mons Available: Legends (Including Celebi)/Gifts and Eggs(Only Gen2). Nature is determined by experience and Shiny Breeding is Available (With Glitched Shiny Ditto + Debug Menu for Speed Up). IVs RNG is available only I don't do Shiny Legends due to there isn't RNG for that.
You can for ask Nature, Shiny, Hidden Power and IVs and TutoEgg Moves.
· RNGed Dittos Available:
-You can ask for any IVs Spread and any Nature.
-TAGs available: ENG-SPA-JPN (The last 2 will have SS of IV calculator due to there isn’t Special Lua Scripts for that languages to view party/wild summary on emulator)
-Games used is White for all.
Spreadsheet with all FT and Prices: https://docs.google.com/spreadsheets/d/1uR9jqdMsJmfI69z05oj1XFrKhuScdrqe2yh4bY7_8lQ/edit?usp=sharing
[ref]https://www.reddit.com/pokemonexchangeref/comments/hruzjp/uvictylusi_exchange_reference/
submitted by VictyLusi to Pokemonexchange

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